Small cell neuroendocrine carcinoma

a case study in gynecologic cytopathology

Authors

  • Bruno Gomes Machado ESS Polytechnic Institute of Lisbon
  • Luís Antunes CUF Descobertas Hospital
  • Paula Mendonça Polytechnic Institute of Lisbon

DOI:

https://doi.org/10.26537/citotech.v0i1.491

Keywords:

Colpocytology;, Small Cell Neuroendocrine Carcinoma

Abstract

The present study shows the case of a 62 years old woman, whose only clinical data was a suspected cervical sarcoma. A liquid-based cytology and biopsies from the cervix and the endometrium were done and sent for diagnostic laboratory. The cytology showed numerous groups of a variable number of monotonous, small and round cells, having scarce cytoplasm in a diathesis background. The nuclei featured molding, hyperchromasia, “salt-and-pepper” chromatin and no nucleoli. Similar observations could be found with the biopsies, where atypical gland-like groups were also detected. This neoplasia showed positive immunostaining for neuron specific enolase, synaptophysin and cytokeratin (AE1/AE3 clone antibodies), and a proliferative activity demonstrated by the nuclear marker Ki67/Mib1 immunorreactivity. The cytological, histological and imunohistochemical findings were consistent with the diagnosis of a small cell neuroendocrine carcinoma. Of all the cervical tumors, this sort of malignancy is one of the rarest and has a very aggressive behavior, with poor prognosis and without effective treatment. Its cause may be related to the Human Papillomavirus infection, but this still remains in study.

Author Biographies

Bruno Gomes Machado, ESS Polytechnic Institute of Lisbon

Lisbon School of Health Technologies – Polytechnic Institute of Lisbon (ESTeSL-IPL), Portugal

Luís Antunes, CUF Descobertas Hospital

CUF Descobertas Hospital, Lisbon, Portugal

Paula Mendonça, Polytechnic Institute of Lisbon

Lisbon School of Health Technologies – Polytechnic Institute of Lisbon (ESTeSL-IPL), Portugal

Published

2015-06:-16

How to Cite

Machado, B. G., Antunes, L., & Mendonça, P. (2015). Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology. Citotech Online - Case Review, (1), 1–7. https://doi.org/10.26537/citotech.v0i1.491