Importance of cytology in the identification of villoglandular adenocarcinoma

  • Ana Correia School of Health – Polytechnic Institute of Porto (ESS-P.PORTO), Portugal
  • Madalena Vilar School of Health – Polytechnic Institute of Porto (ESS-P.PORTO), Portugal
  • Cidália Teixeira Pathology Department of Pedro Hispano Hospital, Local Health Unit of Matosinhos, Portugal
Keywords: Well differentiated villoglandular adenocarcinoma;, Endocervix;, Conventional cytology;, Screening;


Endocervical villoglandular adenocarcinoma is a rare subtype of cervical adenocarcinoma. It arises mainly in young and reproductive age women and it has a lower incidence and better prognosis compared to cervical adenocarcinoma. The present case study refers to a conventional cytology performed on a 48-year-old woman within a screening program carried out at a health center of the Local Health Unit of Matosinhos.
The objective of this study is to verify the importance of the cytological sample collection method for a better observation and interpretation of the cytological findings in rare neoplastic entities, as well as to reinforce the importance of the application of complementary tests for the elaboration of a conclusive diagnosis.
The cytological result of the present case report was atypical glandular cells (AGC) of the endocervical type. Subsequently, a biopsy of the uterine cervix, a conization and a curettage of endocervix were performed, whose histological diagnosis was well differentiated villoglandular adenocarcinoma from the endocervix.